However, the label says aducanumab is indicated for the treatment of Alzheimers, based on reduction in beta-amyloid plaques, one of the hallmarks of the disease. If the confirmatory trial does not verify the drugs benefit, then the FDA could remove the drug from the market. The drugs label recommends for doctors to obtain brain MRIs prior to a patients seventh and 12th infusion of aducanumab in order to monitor for cases of ARIA. It is used to treat people with mild cognitive impairment (MCI) or mild dementia. Its founder, Chief Executive Officer and President is Remi Barbier. Background and Objectives Aducanumab was granted accelerated approval with a conflicting evidence base, near-unanimous Food and Drug Administration Advisory Committee vote to reject approval, and a widely criticized launch price of $56,000 per year. 21 ways to reduce your Alzheimer's risk, backed by research. Call your doctor if you have any unusual problems while receiving this medication. Aducanumab, sold under the brand name Aduhelm, is a medicationdesigned to treat Alzheimer's disease(AD). Our Drug Interaction Checker provides rapid access to tens of thousands of interactions between brand and generic drugs, over-the-counter drugs, and supplements. Safety not established in patients with any pretreatment localized superficial siderosis, 10 brain microhemorrhages, and/or brain hemorrhage >1 cm within 1 year of treatment initiation. Aducanumab is an antibody infusion that recently received FDA approval as a drug that eases symptoms of Alzheimer's disease, especially for people in the early stages. If ultimately approved, aducanumab would become the first drug proven to slow the cognitive decline associated with Alzheimer's. Not studied; not expected to be metabolized by hepatic enzymes. Today, the U.S. Food and Drug Administration approved Aduhelm (aducanumab) for the treatment of Alzheimer's, a debilitating disease affecting 6.2 million Americans. Ask your pharmacist or check the Medication Guide for a list of the ingredients. ADUHELM (Aducanumab) is a monoclonal antibody, new class of medication needed for treatment of AD. The FDA approved aducanumab, also known as Aduhelm, using its " accelerated approval " program, which allows for the earlier approval of a drug for a serious or life-threatening illness even. Aducanumab is the newest clinical treatment for Alzheimer's disease in nearly two decades. Can occur at any time during treatment; most likely to occur within the first 8 doses. The antibody binds to aggregates of the amyloid protein and appears to preferentially target the amyloid plaques in the brain as opposed to those in the blood vessels.. by John Gever, Contributing Writer, MedPage . Call our 24 hours, seven days a week helpline at 800.272.3900. Use a 0.2- or 0.22-micron inline filter. (Photo by Sarah Silbiger/Getty Images), MIDVALE, UT - SEPTEMBER 10: A pharmacy technician grabs a bottle of drugs off a shelve at the central pharmacy of Intermountain Heathcare on September 10, 2018 in Midvale, Utah. Aducanumab is available under the following different brand names: Aduhelm, aducanumab-avwa What Are Side Effects Associated with Using Aducanumab? MRIs are used to surveil for the main adverse event of this, which is quite significant: amyloid-related imaging abnormalities, Schneider said. The wholesale cost of treatment with aducanumab is about $4312 per infusion, making the annual cost around $56,000 for a high dose. May be returned to the refrigerator if the total time at room temperature does not exceed 24 hours. Aduhelm is a monoclonal antibody that reduces the occurrence of amyloid-beta, a protein that causes plaques in the brain. The latest drug used to treat underlying cause of AD and recent studies shown to be efficacious . Biogen said Monday the wholesale cost of treatment with aducanumab which requires an infusion once every four weeks is about $4,312 per infusion, making the annual cost around $56,000 for a high dose. The Prescribing Information for aducanumab provides key facts on aducanumab such as dose, titration, pharmacokinetics, and side effects.The Clinical Studies section describes the clinical trials that led to the approval of aducanumab. No, It's Half Full Sparring over new Alzheimer's drug continues between FDA, critics. Phase III clinical trials are ongoing since 2015. . The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Advise patients of other important precautionary information. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). All Rights Reserved. Advise women to inform their clinician if they are or plan to become pregnant or plan to breast-feed. Obtain a recent (within 1 year) brain MRI. According to the amyloid cascade hypothesis, amyloid beta accumulation results in neurotoxicity that leads to AD. This information does not contain all possible interactions or adverse effects. URL of this page: https://medlineplus.gov/druginfo/meds/a621033.html. Reduction of amyloid beta plaques with aducanumab-avwa was clearly and consistently demonstrated across trials. Consider known benefits of breast-feeding along with mother's clinical need for aducanumab and any potential adverse effects of the drug or disease on the infant. The drug was approved to be administered as an intravenous infusion over about one hour every four weeks. Recommended maintenance dosage starting with infusion 7 (week 24) is 10 mg/kg every 4 weeks. The brain goes on creating beta-amyloid, but aducanumab decreases the amount. People have continued to receive treatments, including infusions such as chemotherapy, with extra precautions such as social distancing and wearing a mask. The drug donepezil, a pill formerly sold under the brand name Aricept and now available generically, was initially approved in the United States in 1996 and is still used often to treat Alzheimers disease. But the medication, which is produced by Biogen under the name . Warnings Aducanumab can cause temporary swelling or bleeding in the brain that usually clears up with time. The drug, which targets the sticky plaque known as . The U.S Food and Drug Administration (FDA) defended its controversial decision to approve the first new Alzheimer's drug since 2003 this week. Usual Adult Dose for Alzheimer's Disease Titration is required for treatment initiation: Doses are infused over 1 hour every 4 weeks: Infusion 1 and 2: 1 mg/kg IV Infusion 3 and 4: 3 mg/kg IV Infusion 5 and 6: 6 mg/kg IV Maintenance dose: 10 mg/kg IV once every 4 weeks Comments: Aducanumab could mean more time for individuals to actively participate in daily life, have sustained independence and hold on to memories longer. When will it be available at my doctor? After an . Aducanumab, which was developed by Biogen and. Shipments of the medication are expected to go out in just a couple of weeks. This indication is approved under accelerated approval based on reduction in amyloid beta plaques observed in patients . The FDA approved it faster than usual -- and against the recommendation of its own advisory panel. (Photo by George Frey/Getty Images), chief of neurology at Memorial Healthcare, brain of someone with Alzheimers disease, University of Maryland School of Medicine, Peripheral and Central Nervous System Drugs Advisory Committee, briefing documents for that committee meeting, causes of Alzheimers disease are not fully understood, Biogens head of global product strategy and commercialization, drugs to help manage symptoms of Alzheimers disease, class of medications called cholinesterase inhibitors. 2022 Cable News Network. Aducanumab was approved through the FDA's Accelerated Approval Program, which provides a path for earlier approval of drugs that treat certain serious conditions. It is the first therapy to demonstrate that removing beta-amyloid, one of the hallmarks of Alzheimers disease, from the brain is reasonably likely to reduce cognitive and functional decline in people living with early Alzheimers. It is not clear how much benefit the drug will have in routine use. IHC along with other hospitals and philanthropies are launching a nonprofit generic drug company called "Civica Rx" to help reduce cost and shortages of generic drugs. It is preceded by a multitude of drugs that have attempted to target A, including five anti A antibodies, all of which failed to demonstrate clinical efficacy in their trials . At the end of a six-hour meeting, the committee rejected the evidence, presented by Biogen and the FDA staff, that aducanumab slows cognitive decline in people who participated in clinical trials. Copyright 2022, Selected Revisions April 27, 2022. Then in November, the FDAs Peripheral and Central Nervous System Drugs Advisory Committee was asked to vote on several questions about evidence of the drugs effectiveness. Throughout the pandemic, our health care systems have adapted. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first. What side effects can this medication cause? Therefore, before using this drug, tell your doctor or pharmacist about all the drugs you use. The most common side effects include amyloid-related imaging abnormalities (ARIA), headache and fall. Aducanumab has minor interactions with no other drugs. aducanumab, or biib037, is a monoclonal igg1 antibody that targets extracellular amyloid- plaques in the brain; similar to gantenerumab, bapineuzumab and solanezumab. It is also important information to carry with you in case of emergencies. In the Alzheimer's brain, abnormal levels of a specific protein clump together to form plaques that collect between neurons and disrupt cell function. The brain goes on creating beta-amyloid, but aducanumab decreases the amount. At Memorial Healthcare in Michigan, the hospitals Institute for Neuroscience has been closely following the drugs development and already has a waiting list of potential patients who may meet the criteria to receive the treatment. Aducanumab is a monoclonal antibody which is a class of medications that are used to treat other neurological disorders. Aduhelm (aducanumab or aducanumab-avwa) is the first medication for Alzheimer's disease that can help lower the amount of beta-amyloid plaques found in the brain, but it's unclear if it can slow disease progression. Aducanumab is used to treat people with Alzheimer's disease. Floor 17 Chicago, IL 60601. At Memorial Healthcare in Michigan, Aburashed said that the building has an infusion center where the treatment can be administered. Aducanumab-avwa has an approximate molecular weight of 146 kDa. D10541 Aducanumab Drug classes [BR:br08332] Neuropsychiatric agent DG01968 Antidementia agent D10541 Aducanumab New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D10541 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D10541 Approval of this therapy underscores the importance of early detection and accurate diagnosis. ARIA seems to occur early in treatment during the first 12 weeks, 16 weeks or so, Schneider said, adding that people with a form of the apolipoprotein gene called APOE4 a risk factor for Alzheimers appear to be at increased risk of such events. Available for Android and iOS devices. Continued approval may be contingent upon verification of clinical benefit (e.g., long-term cognitive changes) in confirmatory studies. Studies were halted and the drug stopped development, Dr. Lon Schneider, Della Martin Chair of Psychiatry and Neuroscience and director of the California Alzheimers Disease Center at the University of Southern California, told CNN on Tuesday. 1, 4 aducanumab is a recombinant antibody derived from patients with slow or absent cognitive decline, and phase 1b clinical trial data have shown patients treated with aducanumab Other drugs on the market only treat symptoms. Aducanumab has moderate interactions with no other drugs. https://reference.medscape.com/drug/aduhelm-aducanumab-4000138. Aducanumab, to be sold under the brand name Aduhelm, was approved to treat patients with Alzheimers disease against the recommendation of an FDA advisory committee that concluded last year there is not enough evidence to support approval of the treatment. What Other Drugs Interact with Aducanumab? The FDA, long story short, working with Biogen since that meeting in November, came about and approved the drug but they didnt approve the drug under the normal conditions of standard approval for substantial effectiveness and safety, he said. Brand name: Aduhelm There is no evidence that aducanumab can restore lost memories or cognitive function. Aducanumab has severe interactions with no other drugs. Assessing Symptoms and Seeking Help, Coronavirus (COVID-19) Alzheimer's and Dementia, COVID-19 Vaccine: Answers for Dementia Caregivers and People Living with Alzheimer's, Now is the Best Time to Talk about Alzheimer's Together, Coronavirus (COVID-19): Tips for Dementia Caregivers, Financial and Legal Planning for Caregivers, Healthcare Appeals for People with Alzheimer's and Other Dementias, The Knight Family Dementia Care Coordination Initiative, Asian Americans and Pacific Islanders and Alzheimer's, Educational Programs and Dementia Care Resources, The International Research Grant Program Council, National Academy of Neuropsychology & Alzheimers Association Funding Opportunity, Part the Cloud-Gates Partnership Grant Program: Bioenergetics and Inflammation, Pilot Awards for Global Brain Health Leaders (Invitation Only), Robert W. Katzman, M.D., Clinical Research Training Scholarship, International Network to Study SARS-CoV-2 Impact on Behavior and Cognition, Alzheimers Association Business Consortium (AABC), Global Biomarker Standardization Consortium (GBSC), Global Alzheimers Association Interactive Network, International Alzheimer's Disease Research Portfolio, Improving State and Federal Response to Coronavirus (COVID-19) in Long-Term Care Settings. Mix the final diluted solution for infusion by gentle inversion; do not shake. The FDA is not requiring any specific diagnostic test. Steady-state concentrations reached by 16 weeks following repeated dosing. In a highly anticipated decision, on June 7 the U.S. Food and Drug Administration approved aducanumab (brand name Aduhelm), the first novel therapy for Alzheimer's in nearly 20 years. Patients are excited for that, too, and if aducanumab is the first step toward that brighter future, patients are eager to be part of it.. There is no evidence that the memory-restoration process works. Amyloid-related imaging abnormalities (ARIA). Aducanumab does not appear to be effective at treating adults with early-stage symptoms, the . There is no information regarding drug interactions with aducanumab in the prescribing information for the drug. Unless your doctor tells you otherwise, continue your normal diet. In response to a question about whether it was reasonable to consider data from that one positive study as the primary evidence of aducanumabs effectiveness for the treatment of early Alzheimers disease, none of the committee members voted yes 10 voted no and one was uncertain. (AP Photo/Charles Krupa), A sign for biotechnology company, Biogen, Inc. is seen on a building in Cambridge, Massachusetts, on March 18, 2017. According to the FDA, aducanumab reduces beta-amyloid plaques, which is reasonably likely to lead to a reduction in clinical decline due to Alzheimers disease. Vials are for single use only; discard unused portions. Aducanumab is the first drug to address the underlying biology of the disease. In case of overdose, call the poison control helpline at 1-800-222-1222. Monitor for amyloid-related imaging abnormalities by obtaining an MRI prior to the 7th and 12th infusions. Accelerated approval based on reduction in amyloid beta plaques (a surrogate marker of response). The Food and Drug Administration (FDA) has granted accelerated approval for the monoclonal antibody, aducanumab (Aduhelm), a first-in-class drug, for treatment for Alzheimer's disease.. Alzheimer's disease can be described as an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and ultimately, the ability to carry out simple tasks. Some people may also have small spots of bleeding in or on the surface of the brain with the swelling, although most people with swelling in areas of the brain do not have symptoms. Biological products are isolated from a variety of natural sources, in contrast to most drugs that are chemically synthesized and whose structure is known. Check with your physician if you have health questions or concerns. Aducanumab Drug Information Aducanumab (Aduhelm TM) is a monoclonal antibody that binds amyloid- aggregates in the brain. Unopened vials: 28C; do not freeze. Aducanumab's mechanism of action is unique in its . All Rights Reserved. Instead, they approved the drug under whats called accelerated approval.. Why the newest Alzheimer's drug is controversial. Aducanumab is approved for patients with Alzheimers disease. To use the sharing features on this page, please enable JavaScript. FDA adviser resigns over approval of new Alzheimer's drug. Another medication known as memantine or Namenda, is used to treat the symptoms of moderate-to-severe Alzheimers disease. Aducanumab (Aduhelm) is a monoclonal antibody that is directed against the beta-amyloid plaques that are one of the proposed mechanisms for the development of Alzheimer's disease. You may report side effects or health problems toFDAat 1-800-FDA-1088. headache, confusion, dizziness, vision changes, or nausea, swelling of the face, lips, mouth, or tongue. Aducanumab-avwa is a recombinant human immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta, and is expressed in a Chinese hamster ovary cell line. It is usually given over an hour once every 4 weeks. The Penn Memory Center is committed to answering these questions and providing the . Aducanumab's prescriber label warns of "amyloid related imaging abnormalities" or ARIA, which can be seen on magnetic resonance imaging or MRI scans as brain swelling or incidents of bleeding in. The European Medicines Agency has said no to approving a new drug for Alzheimer's disease in the EU. 1996-2022 RxList, Inc. All rights reserved. A logo sign outside of the headquarters of Biogen, Inc., in Cambridge, Massachusetts on February 21, 2018. AHFS DI Essentials. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. RxList does not provide medical advice, diagnosis or treatment. How does aducanumab work? Chemical name: Immunoglobulin G1, anti-(human beta-amyloid) (human monoclonal BIIB037 heavy chain), disulfide with human monoclonal BIIB037 kappa-chain, dimer (See Therapy Interruption for Toxicity under Dosage and Administration.). Inform patients that they will be scheduled for MRI scans to monitor for ARIA. This is the first antibody directed treatment for Alzheimers disease that targets the main possible cause of the disease, which many feel is related to the deposition and accumulation of a protein called amyloid beta, Aburashed of Michigan said. But the precise causes of Alzheimers disease are not fully understood and there is also still some debate around whether amyloid beta is the main cause of cognitive impairment in Alzheimers patients and whether removing it will help. tell your doctor if you have or have ever had any medical conditions. (Photo by Kristoffer Tripplaar/Sipa USA)(Sipa via AP Images), WHITE OAK, MD - JULY 20: A sign for the Food And Drug Administration is seen outside of the headquarters on July 20, 2020 in White Oak, Maryland. Keep all appointments with your doctor and the laboratory. If dosing is temporarily suspended, dosing may resume at that same dose and titration schedule. Its something to think about.. That's. It is delivered as a monthly infusion. Your doctor may need to interrupt your treatment or stop your treatment depending on your response to the medication and any side effects that you experience. Aducanumab-avwa injection may cause other side effects. Medical Disclaimer Aducanumab Approved for Treatment of Alzheimers Disease, 225 N. Michigan Ave. We encourage people who are interested in learning more about this treatment, for themselves or a loved one, to have a conversation with their health care provider. Aducanumabs road to FDA approval has been rocky, due to halted trials and a FDA advisory panel not entirely convinced of the drugs effectiveness. Screen for asymptomatic ARIA with brain MRI prior to the 7th infusion (first maintenance dose) and 12th infusion of aducanumab. CAMBRIDGE, Mass. The Penn Memory Center has received many questions from patients and families about the decision and the drug. Eligibility That said, I do wish the clinical efficacy of this "first-in-class" drug were better-established prior to approval. So thats why an MRI is recommended in the labeling at the end of six months, and at the end of 11 months of treatment.. Aducanumab's prescriber label warns of "amyloid related imaging abnormalities" or ARIA, which can be seen on magnetic resonance imaging or MRI scans as brain swelling or incidents of bleeding in. The approval of aducanumab was based on the ability of the drug to reduce amyloid in the brain. The FDA has not approved a novel therapy for Alzheimers disease since 2003. Aducanumab will be sold under the brand name of Aduhelm. Neurology > Alzheimer's Disease Aducanumab Glass Half Empty. Exposure increases proportionally with increasing doses. Your effort and contribution in providing this feedback is much Please select an option below: Aducanumab (Aduhelm) has received accelerated approval as a treatment for Alzheimers disease from the U.S. Food and Drug Administration (FDA). 4 The agent was approved through the FDA's Accelerated Approval Pathway. Your doctor will order certain tests such as magnetic resonance imaging (MRI; a medical test that uses powerful magnets to take pictures of the inside of the body) scans before and during treatment to check your body's response to aducanumab-avwa. All but one member of an independent expert panel -- enlisted to review the drug's effectiveness and make a recommendation to the FDA -- voted against approving the drug. Call your doctor for medical advice about serious side effects or adverse reactions. What Are Side Effects Associated with Using Aducanumab? tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Unopened vials may be stored at room temperature (up to 25C) for a maximum of 3 days. Alzheimer's Association is a not-for-profit 501(c)(3) organization. Aducanumab was approved in the US earlier this year and has been submitted to the Therapeutic Goods Administration in Australia for approval. It is the first new Alzheimer's drug approved by US regulators in almost two decades and has generated global interest. Aducanumab-avwa injection is used to reduce amyloid beta plaque, a protein found in the brain of people with Alzheimer's disease (a brain disease that slowly destroys the memory and ability to think, learn, communicate and handle daily activities). Information is also available online at https://www.poisonhelp.org/help. Aduhelm (aducanumab) is a drug that seeks to halt the decline of brain function and so change the disease progression. Determine the number of vials needed based on the patients actual body weight and recommended dosage. This helps people living with the disease gain earlier access to the treatment. These platforms have enabled disease diagnosis and drug delivery in remote regions. Not known whether aducanumab is associated with risk if used during pregnancy. Drug class: miscellaneous central nervous system agents. Aduhelm is approved under the accelerated approval pathway, which provides patients with a serious disease. Amyloid beta plaque accumulation in the brain is a hallmark feature of Alzheimer's disease and is hypothesized to contribute to the pathogenesis of cognitive decline. Aducanumab, which will be sold under the brand name Aduhelm, was cleared by the U.S. Food and Drug Administration (FDA) on June 7, making it the first medicine on the market that aims to slow the progression of Alzheimer's disease, not just treat its symptoms. ADUHELM (aducanumab-avwa) injection, for intravenous use . Donepezil and others like it, such galantamine and rivastigmine, belong to a class of medications called cholinesterase inhibitors, typically prescribed for mild to moderate Alzheimers disease. Drug class: miscellaneous central nervous system agents Aducanumab systemic is used in the treatment of: Alzheimer's Disease See also Search the entire Drugs.com site for aducanumab Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This may cause no symptoms but can be serious. Medically reviewed by Drugs.com on Apr 27, 2022. Causes and Risk Factors for Alzheimer's Disease, Difference Between Alzheimer's & Dementia, 10 Steps to Approach Memory Concerns in Others, Medications for Memory, Cognition and Dementia-Related Behaviors, What Causes Memory Loss? Discovery Company. 8:06 AM EDT, Thu June 10, 2021, A pedestrian walks past Biogen Inc. headquarters in Cambridge, Massachusetts, U.S., on Monday, June 7, 2021. ARIA typically presents as temporary swelling of areas in the brain that usually resolves over time. Aducanumab is the first putative DMT to demonstrate a clinical effect in early AD patients in a Phase III study and the first to undergo regulatory review. At Memorial Healthcare Institute for Neuroscience, we intend to be very focused on this subset of patients for treatment consideration, given some of the risks surrounding the drug., In controversial decision, FDA approves first new Alzheimer's disease drug in nearly 20 years. Aducanumab comes with a hefty price tag. CAS number: 1384260-65-4. | All rights reserved. Discontinue if radiographic severe ARIA-H is observed. Another potentially serious side effect is allergic reaction. It should be given as an intravenous (IV) infusion over one hour every four weeks and at least 21 days apart using a sterile, low-protein binding, 0.2 or 0.22 micron in-line filter. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. See additional information. Withdraw the required volume of aducanumab and add to infusion bag containing 100 mL of 0.9% sodium chloride injection; do not use any other diluents. Aducanumab (Aduhelm) has been approved by the US Food and Drug Administration (FDA) for the treatment of Alzheimer's disease (AD). Duplication for commercial use must be authorized by ASHP. Visit the RxList Drug Interaction Checker for any drug interactions. Allow the diluted solution to warm up to room temperature prior to infusion. My own decision to prescribe it will be made in collaboration with the patient, and based on the patients age, imaging findings to rule out contraindications, type and severity of symptoms, risk factors and overall diagnostic impression.. The FDA approved aducanumab under accelerated approval based on reduction in amyloid plaques in patients treated with this medication in clinical trials. So we would be getting to know whether someone is amyloid positive on a PET scan. Protect from light; store in original carton until use. Diluted solution: May store at 28C for up to 3 days or at room temperature (up to 30C) for up to 12 hours. [1][2]It is an amyloid beta-directed monoclonal antibody[1][2]that targets aggregated forms (plaque) [3][4]of amyloid beta(A) found in the brains of people with Alzheimer's disease to reduce its buildup. Hospitals are on tap to administer treatment when needed. How much does aducanumab cost? It works by blocking the formation of amyloid beta in the brain. Aducanumab is available under the following different brand names: swelling of the face, lips, tongue, or throat, Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or. The following tables describe changes to the AHFS Pharmacologic-Therapeutic Classification that will be published in the 2021 edition of AHFS Drug Information (February 1, 2021), as well as any new classes added after the publication of the 2020 edition. Aducanumab is the first disease-modifying therapy approved by the FDA and the first AD drug approved since 2003. Aducanumab may be a treatment option. However, the pharmaceutical company Biogen and its Japanese partner Eisai tested aducanumab, administered through intravenous infusion, in patients with mild cognitive impairment, the impaired thinking and memory loss that often develops into dementia.
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