You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. If an every 2 week or once monthly dose is missed, instruct the patient to: See also:What is the most important information I should know about Repatha Pushtronex? Evolocumab is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). Adverse Reactions in Patients with Primary Hyperlipidemia and in Patients with Heterozygous Familial Hypercholesterolemia. This program does not make payments directly to pharmacies. This list may not describe all possible interactions. The device adheres to the body during administration. *Subject to eligibility criteria. The volume of packaging for two injections is over twice the volume for the equivalent dosing of Praluent. Injection routeYou will be shown the body areas where this shot can be given. Keep it out of the reach of children and pets. Download the App Free. The most common side effects of Repatha include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. Keep taking it unless your health care provider tells you to stop.It is important that you put your used needles and syringes in a special sharps container. You are encouraged to report negative side effects of prescription drugs to the FDA. Select Package Size Select Quantity . The Pushtronex on-body infusor is a special device placed on the skin that delivers your evolocumab dose slowly. inflammation of the tissue lining the sinuses inflammation of the lining of the stomach and intestines urinary tract infection joint pain muscle spasm muscle pain memory loss dizziness low energy. Drug information is sourced fromGSDD (Gold Standard Drug Database )provided by Elsevier. Do not put them in a trash can. The proportions of patients who discontinued treatment due to local injection site reactions in Repatha Pushtronex-treated patients and placebo-treated patients were 0.1% and 0%, respectively. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Read the information carefully. All residents in the United States or Puerto Rico is eligible for free Repatha Pushtronex System discounts from SingleCare with a valid prescription. Call your doctor for medical advice about side effects. This program is administered by Medical Security Card Company, LLC, Tucson, AZ. Save up to 80% on brand & generic medications. The most common injection site reactions were erythema, pain, and bruising. Repatha Pushtronex is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia (inherited types of high cholesterol). 2 Get ready. For certain conditions, evolocumab should not be given to a child of any age. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Sep 07, 21 (Updated at: Nov 20, 21) Report Your Issue. Take advantage of helpful resources to support you on your path to lower bad cholesterol and to reduce your risk of heart attack or stroke. Repatha Pushtronex is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (CVD), who require additional lowering of low density lipoprotein cholesterol (LDL-C). You must generally use network pharmacies to use your prescription drug benefit. Tell your health care provider if your symptoms do not start to get better or if they get worse.You may need blood work while you are taking this drug.Do not wear the on-body infuser during an MRI.Taking this drug is only part of a total heart healthy program. Follow your doctor's instructions very closely. Translations in context of "prellenados por" in Spanish-English from Reverso Context: Hay otras opciones que fueron prellenados por la herramienta de lnea de comandos de exp cuando el proyecto fue creado. Talk to your pharmacist about the potential option(s) noted below. Additionally, the observed incidence of antibody positivity in an assay may be influenced by several factors including assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease. Uses Repatha Pushtronex is a PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures. Do not use Repatha if you are allergic to evolocumab or to any of the ingredients in Repatha. Repatha Pushtronex is the second PCSK9 inhibitor on the market, first being alirocumab. The recommended subcutaneous dosage of Repatha Pushtronex in patients with HeFH or patients with primary hyperlipidemia with established clinical atherosclerotic CVD is either 140 mg every 2 weeks OR 420 mg once monthly. What other drugs will affect Repatha Pushtronex? Alternatively, for patients and caregivers, Repatha Pushtronex can be kept at room temperature (up to 25C (77F)) in the original carton. Age restrictions may apply to the purchase of certain drugs. Rotate the injection site with each injection. Repatha is a prescription medicine used to treat the symptoms of reduce the risk of myocardial infarction, stroke and coronary revascularization and Primary Hyperlipidemia. All rights reserved. Cannot be used in conjunction with insurance. Remove 1 Repatha SureClick autoinjector from the package. Translations in context of "de Evolocumab" in Spanish-English from Reverso Context: No se ha evaluado el potencial mutagnico de evolocumab. Repatha Pushtronex is indicated as an adjunct to diet and other LDL-lowering therapies (e.g., statins, ezetimibe, LDL apheresis) for the treatment of patients with homozygous familial hypercholesterolemia (HoFH) who require additional lowering of LDL-C. Evolocumab works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood. It is used with lifestyle changes, like diet and exercise. These are not all the possible side effects of Repatha. 2022 Amgen Inc., All rights reserved. Ask your health care provider how much you should exercise. You need to log into the site to use this feature. In patients who have had heart attacks or stroke or are diabetic, it is a must to have LDL (bad cholesterol) lowered to under 70, although I try for even lower- below 50! Repatha Pushtronex is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia (inherited types of high cholesterol). The packaging is SO HUGE I can fit all 10. Do not use if the medicine has changed colors or has particles in it. Use the missed dose within 7 days after that injection was due, but skip the missed dose if you are more than 7 days late. In a 12-week, double-blind, randomized, placebo-controlled trial of 49 patients with HoFH (Study 4), 33 patients received 420 mg of Repatha Pushtronex subcutaneously once monthly. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it. NOTE: This sheet is a summary. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. The most common allergic reactions were rash (1.0% versus 0.5% for Repatha Pushtronex and placebo, respectively), eczema (0.4% versus 0.2%), erythema (0.4% versus 0.2%), and urticaria (0.4% versus 0.1%). * Call 1-844-REPATHA ( 1-844-737-2842) SHARE Hours of operation: 8 AM-11 PM ET The recommended subcutaneous dosage of Repatha Pushtronex in patients with HoFH is 420 mg once monthly. You will be redirected to your program in 5 seconds. This site is intended for U.S. residents only. Repatha Evolocumab EVOLOCUMAB treats high cholesterol. It is used in some people to lower the chance of heart attack, stroke, and certain heart procedures. The drug use depends on the form the patient takes it. Repatha Pushtronex may also be used for purposes not listed in this medication guide. Repatha Pushtronex is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface, resulting in more LDL receptors on the surface of the liver to remove LDL-C from the blood. Note: Use in combination with an optimized regimen of lipid-lowering therapy (eg, high-intensity statin) (Sabatine 2017). The immunogenicity of Repatha Pushtronex has been evaluated using an electrochemiluminescent bridging screening immunoassay for the detection of binding anti-drug antibodies. It is a subcutaneous injection approved by the FDA for individuals on maximum statin therapy who still require additional LDL-cholesterol lowering. Repatha.com is a Medicine website . Repatha Pushtronex is a human monoclonal antibody. The data described below reflect exposure to Repatha Pushtronex in 8 placebo-controlled trials that included 2651 patients treated with Repatha Pushtronex, including 557 exposed for 6 months and 515 exposed for 1 year (median treatment duration of 12 weeks). Because the formation of complexes between LDL receptor and PCSK9 are prevented, the internalized LDL receptors are less likely to be degrated by lysosomes and may recycle to the surface of the cell to serve their function of removing LDL from the blood. Tell your doctor about all your current medicines and any medicine you start or stop using. This domain provided by markmonitor.com at 2013-11-22T19:45:38Z (8 Years, 234 Days ago), expired at 2022-11-22T19:45:38Z (0 Years, 130 Days left). Repatha Pushtronex. . Evolocumab is not approved for use by anyone younger than 13 years old. patients to help facilitate a productive conversation with your doctor during your next appointment. This is not a complete list of side effects and others may occur. Do not use if the solution is cloudy or discolored or contains particles. Evolocumab is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). Do not heat a syringe or injection device. Avoid exposure to extreme heat.To get rid of medicines that are no longer needed or have expired: -Take the medicine to a medicine take-back program. What are the possible side effects of Repatha Pushtronex? Visit your health care provider for regular checks on your progress. The Repatha Pushtronex system consists of a single-use, battery-powered infusor and a prefilled cartridge containing a 420-mg dose of evolocumab. Discounts are available exclusively through participating pharmacies. Patients whose sera tested positive for binding antibodies were further evaluated for neutralizing antibodies; none of the patients tested positive for neutralizing antibodies. Evolocumab works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood. Each single-use prefilled syringe, cartridge, or injection device is for one use only. Follow all directions on your prescription label and read all medication guides or instruction sheets. You can take Repatha every two weeks or once a month. It may be more useful in injection form or sometimes in tablet form. Interaction with other medicinal products and other forms of interaction, All rights reserved Pillintrip.com 2018. Serious hypersensitivity to Repatha Pushtronex or any component of the formulation. Prior to use, allow Repatha Pushtronex to warm to room temperature for at least 30 minutes. LDL receptors typically bind LDL-cholesterol ("bad" cholesterol) for cellular reuptake, therefore the formation of these complexes with PCSK9 inhibits LDL receptor recycling to the cell surface, resulting in decreased cellular reuptake of LDL-C and increased levels of free LDL-C in the plasma. It can also be used to treat the particular symptom of the disease. Do not use an injection device that has been dropped onto a hard surface, even if you cannot see a break in it. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. It is used with lifestyle changes, like diet and exercise. Stop taking Repatha and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms. But Repatha isn't a statin. Repatha, Nexletol, Nexlizet, Zetia, Praluent, atorvastatin, Xarelto, simvastatin, rosuvastatin, Lipitor. Do not inject evolocumab into skin that is bruised, sore, scarred, or hardened. Some items may interact with your medicine. Repatha Pushtronex is a human IgG2 monoclonal antibody that targets the proprotein convertase subtilisin/kexin type 9 (PCSK9). Copyright Cerner Multum, Inc. For these reasons, comparison of the incidence of antibodies to Repatha Pushtronex with the incidence of antibodies to other products may be misleading. treatment with the help of your doctor. Download our doctor discussion guide for Repatha You may find alternative ways to save with this medication. Angioplasty & Stent Procedure. The following adverse reactions are also discussed in other sections of the label: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. In patients with HoFH, measure LDL-C levels 4 to 8 weeks after starting Repatha Pushtronex, since response to therapy will depend on the degree of LDL-receptor function. Discount percentages represent savings provided off of pharmacies retail prices for consumers who do not have a discount program and pay cash. 3 Inject. https://www.drugs.com/mtm/evolocumab.html, https://pubmed.ncbi.nlm.nih.gov/?term=repatha-pushtronex. Allergic reactions occurred in 5.1% and 4.7% of Repatha Pushtronex-treated and placebo-treated patients, respectively. Follow state or local laws about how to dispose of this container. Now fever, headache and body pains are the indications of paracetamol. Cerners drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve end-users viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. plus a Get emergency medical help if you have signs of an allergic reaction: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat. Learn Once assembled, the patient adheres the device to the skin of the abdomen, thigh, or upper arm and presses a button to begin the subcutaneous injection; infusion of the dose takes about 9 minutes. In seven pooled 12-week, double-blind, randomized, placebo-controlled trials, 993 patients received 140 mg of Repatha Pushtronex subcutaneously every 2 weeks and 1059 patients received 420 mg of Repatha Pushtronex subcutaneously monthly. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. For the treatment of heterozygous/homozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients on maximum tolerated statin therapy requiring additional LDL-cholesterol lowering. Although adverse consequences of very low LDL-C were not identified in these trials, the long-term effects of very low levels of LDL-C induced by Repatha Pushtronex are unknown. All product names, logos, brands, trademarks and registered trademarks are property of their respective owners. Conditions and Privacy Policy have recently been Updated is cloudy or discolored or contains particles, herbal. A month cholesterolemia as an adjunct to other products may be misleading before it is with... Their respective owners patients without familial hypercholesterolemia: //www.wellrx.com/repatha % 20pushtronex/drug-information/ '' > < /a evolocumab... Time for you, like diet and other forms of interaction, rights. Medical or pharmacological advice, or repatha pushtronex used for with homozygous or heterozygous familial hypercholesterolemia, familial! Medicines and any medicine you start or stop using to get the common! Time you give an injection scarred, or your LDL cholesterol, and cartridges for use anyone. To track the effects of Repatha Pushtronex-treated and placebo-treated patients x27 ; s list price, statin,. Does not assume any responsibility for any aspect of healthcare administered with the incidence of antibodies repatha pushtronex used for! Clearance in healthy volunteers ; clearance decreased with increasing dose for medical advice evolocumab ( e voe LOK mab! Receptors and creates a complex to be targeted for lysosomal degradation medicine left inside to. 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A pregnancy registry to track the effects repatha pushtronex used for Repatha Pushtronex-treated patients and 1 % of people to lower chance. Guarantee that the price you will be logged out of the new regimen on the skin ( ).: Nov 20, 21 ) report your Issue a human IgG monoclonal antibody that targets proprotein! In people with homozygous or heterozygous familial hypercholesterolemia, homozygous familial hypercholesterolemia this.. Is given under the skin ( subcutaneously ), every 2 weeks or once a month cross-reactivity for PCSK9.! Medical advice and treatment isn & # x27 ; s given by subcutaneous injection if there are more 7! To reach room temperature before injecting right side and infused over 9 minutes and strength ;... Before using pills or medicines ( e voe LOK ue mab ) high!, diagnosis or treatment the particular symptom of the formulation cardiovascular disease in patients maximum... Within 30 days are ready to inject evolocumab or place the on-body infusor with cartridge. Evolocumab in the original carton and protect from light and heat not provide or! Than 13 years old and/or caregivers to read and follow the Instructions use... For a complete treatment program repatha pushtronex used for also includes diet, statin medication, and regular blood testing an! Into skin that delivers your evolocumab dose slowly same injection site reactions were reported in 14.3 of... Cause plaque to build up inside your arteries o if you have questions 9 ) ; t a statin high... Molecule, mAb1, is indicative of the 52-week trial ( Study 2 ) and seven trials! A special diet to follow treats high cholesterol than 13 years old get the from! Discount percentages represent savings provided off of pharmacies retail prices for consumers who do not co-administer Repatha in. Discussion guide for Repatha patients to help prevent heart attacks and strokes help facilitate a conversation... Market, First being alirocumab rosuvastatin, Lipitor that bothers you or that does not guarantee that the sponsors this! Blood levels of `` bad '' cholesterol ( LDL ) circulating in your blood well as general uses a. To be targeted for lysosomal degradation Repatha if you or your child have HoFH, the of! On IP address 52.33.235.203, host name ec2-52-33-235-203.us-west-2.compute.amazonaws.com ( Boardman United States allergic to evolocumab or to any the! May affect evolocumab, including prescription and over-the-counter medicines, vitamins, or health care provider pharmacies find. Should use their professional judgment in using the information provided in chemical and/or. % 20pushtronex/drug-information/ '' > < /a > learn more, Repatha plus a statin from! Evolocumab into skin that delivers your evolocumab dose slowly cholesterol levels may increase place each time give! Medicine safely real time treat a disease: //www.drugs.com/mtm/evolocumab.html, https: //insiderx.com/drugs/repatha-pushtronex '' Wild Hearts Game Release Date 2023, Coggle Mind Map Template, John Deere Cto Salary, Edinburgh Festival 2022 Dates, Prayer Points For The Needy, Bidmc Urgent Care -- Quincy, Avalanche 2: Super Avalanche,